Linda Partridge, the founding director of Max Planck Institute of Aging, Germany, and other five authoritative scientists updated and improved the Cellular senescence logo based on the aging research in the past 10 years, and published an authoritative review of "12 aging logos" on the top scientific journal Cell, providing theoretical support for anti-aging product research and development for K2LT'S!
The field of aging research has identified 12 markers that represent common characteristics of aging in different organisms. Identification of genomic instability: DNA methylation
DNA methylation plays an important role in cell differentiation, embryonic development, environmental adaptation, and disease occurrence and development by Regulator gene transcription, imprinting, X chromosome inactivation, and defending the invasion of exogenous Genetic material. It is one of the hot areas of current Epigenetics research.
DNA methylation is a form of DNA chemical modification, which can change the genetic performance without changing the DNA sequence. A large number of studies have shown that DNA methylation can cause changes in Chromatin structure, DNA conformation, DNA stability and the Mode of action between DNA and protein, thus controlling gene expression. DNA methylation capsules can maintain the stability of genetic information, gene expression patterns and stability, embryonic development and selective expression of alleles.
There are more than 200 different types of cells in the human body, which not only have different cell differentiation related DNA methylation profiles, but also have adaptation related DNA methylation profiles that change with the changes of living environment factors and age. Obviously, compared with genome, epigenetic groups such as DNA methylation group in human body are more complex and diverse, and the research work is particularly arduous. How can human ESC with identical DNA genome sequences differentiate into different cells? How does DNA methylation coordinate with other epigenetic networks? How do these networks effectively adapt to changes in different living environment factors? What role do these networks play in the process of disease occurrence? What can be used for disease prevention, diagnosis, and treatment? These are still hot issues that need to be clarified. The epigenetic phenomenon is extremely complex. On the one hand, outstanding scientists need to continue to work creatively to reveal the basic laws of the startup, expansion, maintenance and removal of epigenetic networks such as DNA methylation. On the other hand, considerable resources need to be invested to develop sensitive and reliable low-cost single-cell analysis technology to analyze the impact of DNA methylation on disease occurrence, environmental factor safety The role and mechanism in increasing crop yield and disease resistance, and studying its potential application value. With the reduction of the cost of deep sequencing and the emergence of various data mining software, the research on comparative epigenemics between different types of cells and between different species in animals is expected to flourish, and the evolutionary mechanism of DNA methylation is expected to be revealed.
Predicting the sensitivity of methylurea chemotherapy drugs using cyclic MGMT methylation has started to be used in clinical trials; The DNA methylation blocker deoxazacytidine has been approved for clinical treatment of myelodysplastic syndrome, and has begun to expand to other tumor species. China is a country with large disease resources and human resources. The current upsurge of translational medicine research has led to the continuous development of research on the relationship between DNA methylation and disease all over the country. In the near future, a batch of DNA methylation products with clinical use are expected to emerge.
K2- Changshou Technology Club takes advantage of the trend. A patent for the application of DNA methylation composition came out. It's like 'enlightenment', and sometimes enlightenment is like a sudden flash of inspiration, and sometimes it's like finding the right number for the safe, the kind of thing that happens at the touch of a trigger but makes the right choice.
DNA methylation, using Epigenetics and potential therapeutic targets, DNA methylation and histone acetylation abnormalities play a role in promoting the occurrence and development of diseases. Due to the fact that epigenetic modification is a reversible process, changes in epigenetic modification under disease conditions provide a good target for the treatment of diseases. New drugs that regulate methylation levels and acetylation states are gradually emerging.
DNA methylation uses Epigenetics and potential therapeutic targets to combine Betaine, folic acid, lycium barbarum polysaccharide, and black pepper extract to effectively maintain the stability of genetic information, prevent DNA methylation, and provide the human body with collagen and natural mineral nutrients, embryonic development, and selective expression of alleles.
DNA methylation is an important means of gene expression regulation. DNA methylation plays a crucial role in maintaining the function of normal cells, inactivation of female X chromosome, inhibition of parasitic DNA sequence, stability of genome structure, genetic imprinting, embryonic development, and the occurrence and development of tumors and diseases. In addition, abnormal changes of DNA methylation status are common in various tumors, and abnormal DNA methylation status is one of the important characteristics of tumors. The DNA methylation composition can maintain the stability of genetic information, gene expression mode and stability, embryonic development and selective expression of alleles.
The 12 major anti-aging signs of K2 longevity technology: change of intercellular communication, Cellular senescence, runaway nutrition induction, loss of protein homeostasis, prohibition of megaautophagy, ecological imbalance, epigenetic changes, genomic instability, mitochondrial dysfunction, stem cell failure, telomere depletion, chronic inflammation; We all apply cutting-edge life technology to provide consumers with safe and efficient pure natural, anti-cell aging high-tech products, intelligent combination and technology formula, significantly improving human lifespan.
K2- Longevity Technology - From cutting-edge technology in the United States