Thanks to modern diets, lifestyle changes, and scientific advances, our life expectancy increases with each generation.
However, this increased life expectancy has not been coupled with a corresponding increase in healthspan. In fact, aging brings with it the prevalence of age-related health problems, and aging is now known to be the greatest risk factor for poor health.
The aging process is an increasingly popular subject of research, research and publications, with mounting evidence that, in addition to a healthy lifestyle, supplementing with nutraceuticals can support healthy cellular function and overall well-being. K2LT'S curated this research to formulate nutraceuticals to support your long-term health and healthy aging.
Our lifespans are increasing, but our healthspans are not keeping up.
There are many reasons why we should worry about our short healthspan. We want a future where we can continue to do the activities we love, spend time with loved ones, and maintain our independence throughout our golden years. But for many, the reality can be very different.
With recent and upcoming scientific advances, we now know that there are ways to support our bodies during the aging process. What we're only now starting to look forward to is that we might be able to live those extra years well. Energetic, enthusiastic, flexible and consciously recognized.
To realize this vision, we need to understand what causes aging at the cellular level.
12 signs and applications of human aging
Linda Partridge, the founding director of the Max Planck Institute for Aging in Germany, and other five authoritative scientists have updated and improved cell aging markers based on the aging research of the past 10 years, and published an authoritative review of "Twelve Major Signs of Aging" in the top scientific journal <Cell> , providing K2LT'S with theoretical support for anti-aging product development!
The field of aging research has identified 12 hallmarks that represent common features of aging in different organisms.
Why is this important? These established hallmarks provide a blueprint for what we can do to slow the worsening process of aging.
1. Altered cell-to-cell communication
As we age, our cells become less effective at communicating with each other. This manifests itself in many ways, including a weakened immune system and disruption of hormone levels and systemic blood factors;
2. Cell Senescence
Cells enter a senescent state after dividing too many times or responding to things like DNA damage, oxidative stress and mutations, replenish NAD+ , eliminate senescent cells, activate longevity factors;
3. Runaway Nutrient Sensing
Pathways that sense and respond to nutrients are consistent regulators of lifespan in both simple and complex animals. The effectiveness of these pathways decreases with age, which increases the likelihood of developing type 2 diabetes and other metabolic disorders.
4. Loss of protein homeostasis
Proteins are workers who perform necessary tasks, and in order to work properly, new proteins must be properly folded and old proteins must be disposed of efficiently. As we age and with different neurological disorders such as Alzheimer's disease, proteins misfold and accumulate in harmful aggregates.
5. Disable macroautophagy
Autophagy, which declines with age, refers to a cellular recycling program that removes old and damaged cellular components such as mitochondria and proteins.
6. Dysbiosis
The gut microbiota plays an important role in the production of metabolites, nutrient absorption, and immunity, and undergoes major changes with age. Major changes include a loss of biodiversity and a reduction in the number of beneficial microbes.
7. Epigenetic changes
Epigenetic changes are modifiable and can affect gene expression. Over time, the epigenome becomes dysregulated, which causes genes that should be turned off to be turned on, and vice versa. DNA methylation is an epigenetic modification that generally declines with age.
8. Genome instability
Our cells are constantly making and repairing DNA. While the machines that do this are highly efficient, errors inevitably occur, and mutations increase with age. Some of these mutations are harmful, such as those that cause cancer.
9. Mitochondrial Dysfunction
Mitochondria are the reactors in our cells that generate the energy needed for life. These cellular machines have their own DNA, generate free radicals, and can induce cell death in response to damage. Mitochondrial efficiency decreases over time.
10. Stem cell exhaustion
Stem cells have the unique ability to transform into many different types of cells. Because of this, they can replenish cells as they die. However, the number of stem cells in our body decreases with age, which leads to a decreased ability to regenerate.
11. Telomere loss
Telomeres are the protective caps on the ends of our chromosomes that shorten each time a cell divides. When they become too short, cells age and enter a zombie-like state.
12. Chronic inflammation
Inflammation increases with age as senescent cells and infectious pathogens accumulate over time. This phenomenon is called "inflammation," and although senescent cells are no longer able to divide, they accumulate with age and secrete pro-inflammatory molecules that wreak havoc on their environment.
Each of the above traits manifests itself in our bodies as aging. Externally we can see changes in skin elasticity, hair color and skin pigmentation. We feel the challenges associated with lack of sleep and a general drop in energy. Internally, these changes can be observed through changes in autophagy, NAD+ levels, and telomere structure.
Our system recognizes the different levels of support needed at different stages of your biological age.
KINGAMX nutrition is not one size fits all - as you age, your cells can use support in different areas, which is why we recommend different products to you based on your biological age or lifestyle factors.